Details

Autor(en) / Beteiligte

• Jin, Hongxing
• Zhang, Qinglong
• Li, Erqing
• Jia, Penghao
• Li, Ning
• Huang, You

Titel

Phosphine-catalyzed intramolecular Rauhut-Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives

Ist Teil von

• Organic & biomolecular chemistry, 2017-08, Vol.15 (34), p.7097-7101

Ort / Verlag

England

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A highly enantioselective intramolecular Rauhut-Currier reaction catalyzed by a multifunctional chiral aminophosphine catalyst was reported. A series of hydro-2H-indole derivatives that bear an all-carbon quaternary center were obtained in high yields (up to 94%), and excellent diastereo- and enantioselectivities (up to >20 : 1 dr and >99% ee). And this reaction could be performed on a gram scale using 2 mol% catalyst loading.