American journal of physiology. Regulatory, integrative and comparative physiology, 2017-10, Vol.313 (4), p.R395-R399
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Prenatal hypoxia and placental oxidative stress: linkages to developmental origins of cardiovascular disease
- Ist Teil von
- American journal of physiology. Regulatory, integrative and comparative physiology, 2017-10, Vol.313 (4), p.R395-R399
- Ort / Verlag
- United States: American Physiological Society
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Intrauterine growth restriction (IUGR, a pregnancy complication where the fetus does not reach its genetic growth potential) is a leading cause of fetal morbidity and mortality with a significant impact on population health. IUGR is associated with gestational hypoxia; which can lead to placental oxidative stress and fetal programming of cardiovascular disease. Mitochondria are a major source of placental oxidative stress and may provide a therapeutic target to mitigate the detrimental effects of placental oxidative stress on pregnancy outcomes. A nanoparticle-mediated delivery of a mitochondrial antioxidant to the placenta is a potential novel approach that may avoid unwanted off-target effects on the developing offspring.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0363-6119eISSN: 1522-1490DOI: 10.1152/ajpregu.00245.2017Titel-ID: cdi_proquest_miscellaneous_1927829194
- Format
- –
- Schlagworte
- Animals, Antioxidants, Cardiovascular disease, Cardiovascular diseases, Cardiovascular Diseases - etiology, Cardiovascular Diseases - metabolism, Female, Fetal Development - physiology, Fetal Growth Retardation - metabolism, Fetuses, Humans, Hypoxia, Hypoxia - metabolism, Linkages, Mitochondria, Morbidity, Nanoparticles, Offspring, Oxidative stress, Oxidative Stress - physiology, Placenta, Placenta - metabolism, Placental Insufficiency - metabolism, Pregnancy