The American journal of gastroenterology, 2017-10, Vol.112 (10), p.1509-1525
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management
- Ist Teil von
- The American journal of gastroenterology, 2017-10, Vol.112 (10), p.1509-1525
- Ort / Verlag
- United States: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Colorectal cancer (CRC) is the fourth most common cancer amongst men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and several hamartomatous polyposis conditions. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This narrative review examines the hereditary colorectal cancer and polyposis syndromes, their genetic basis, clinical management, and evidence supporting cancer screening.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0002-9270eISSN: 1572-0241DOI: 10.1038/ajg.2017.212Titel-ID: cdi_proquest_miscellaneous_1927304840
- Format
- –
- Schlagworte
- Adenomatous Polyposis Coli - diagnosis, Adenomatous Polyposis Coli - therapy, Colorectal cancer, Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis - therapy, Disease Management, Early Detection of Cancer - methods, Genetic disorders, Genetic Predisposition to Disease, Genetic Testing - methods, Humans, Medical History Taking - methods, Medical screening, Polyps