Zhongguo dang dai er ke za zhi, 2017-08, Vol.19 (8), p.930-937
2017
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Effect of baicalin on behavioral characteristics of rats with attention deficit hyperactivity disorder
- Ist Teil von
- Zhongguo dang dai er ke za zhi, 2017-08, Vol.19 (8), p.930-937
- Ort / Verlag
- China
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the effect of baicalin on the behavioral characteristics of rats with attention deficit hyperactivity disorder (ADHD), and to provide a basis for further research on baicalin in the treatment of ADHD. A total of 40 SHR rats were randomly divided into model group, methylphenidate hydrochloride (MPH) group, and low-, medium-, and high-dose baicalin groups, with 8 rats in each group. Eight WKY rats were selected as normal control group. The rats in the MPH group (0.07 mg/mL) and the low- (3.33 mg/mL), medium- (6.67 mg/mL), and high-dose (10 mg/mL) baicalin groups were given the corresponding drugs (1.5 mL/100 g) by gavage twice a day, and those in the normal control group and the model group were given an equal volume of normal saline by gavage twice a day. The course of treatment was 4 weeks for all groups. The open field test was performed to observe total moving distance and average moving speed on day 0 of experiment and at 7, 14, 21, and 28 days after gavage and to evaluate the control effect
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1008-8830DOI: 10.7499/j.issn.1008-8830.2017.08.016Titel-ID: cdi_proquest_miscellaneous_1926680687
- Format
- –
- Schlagworte
- Animals, Attention Deficit Disorder with Hyperactivity - drug therapy, Attention Deficit Disorder with Hyperactivity - psychology, Behavior, Animal - drug effects, Dose-Response Relationship, Drug, Flavonoids - therapeutic use, Male, Maze Learning - drug effects, Motor Activity - drug effects, Rats, Rats, Inbred SHR, Rats, Inbred WKY