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A pilot study for texture analysis of 18F-FDG and 18F-FLT-PET/CT to predict tumor recurrence of patients with colorectal cancer who received surgery
Ist Teil von
European journal of nuclear medicine and molecular imaging, 2017-12, Vol.44 (13), p.2158-2168
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2017
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Purpose
This retrospective study was done to examine whether the heterogeneity in primary tumor F-18-fluorodeoxyglucose (
18
F-FDG) and
18
F-3′-fluoro-3′-deoxythymidine (
18
F-FLT) distribution can predict prognosis of patients with colorectal cancer who received surgery.
Methods
The enrolled 32 patients with colorectal cancer underwent both
18
F-FDG- and
18
F-FLT-PET/CT studies before surgery. Clinicopathological factors, stage, SUVmax, SUVmean, metabolic tumor volume (SUV ≥ 2.5), total lesion glycolysis, total lesion proliferation and seven texture heterogeneity parameters (coefficient of variation, local parameters: entropy, homogeneity, and dissimilarity; and regional parameters: intensity variability [IV], size-zone variability [SZV], and zone percentage [ZP]) were obtained. Progression free survival (PFS) was calculated by the Kaplan-Meier method. Prognostic significance was assessed by Cox proportional hazards analysis.
Results
Eight patients had eventually come to progression, and 24 patients were alive without progression during clinical follow-up [mean follow-up PFS; 55.9 months (range, 1-72)]. High stage (
p
= 0.004), high
18
F-FDG-IV (
p
= 0.015), high
18
F-FDG-SZV (
p
= 0.013) and high
18
F-FLT-entropy (
p
= 0.015) were significant in predicting poor 5-year PFS. Other parameters did not predict the disease outcome. At bivariate analysis, disease event hazards ratios for
18
F-FDG-IV and
18
F-FDG-SZV remained significant when adjusted for stage and
18
F-FLT-entropy (
18
F-FDG-IV;
p
= 0.004 [adjusted for stage], 0.007 [adjusted for
18
F-FLT-entropy];
18
F-FDG-SZV;
p
= 0.028 [adjusted for stage], 0.040 [adjusted for
18
F-FLT-entropy]).
Conclusion
18
F-FDG PET heterogeneity parameters, IV and SZV, have a potential to be strong prognostic factors to predict PFS of patients with surgically resected colorectal cancer and are more useful than
18
F-FLT-PET/CT heterogeneity parameters.