Cancer research (Chicago, Ill.), 2017-09, Vol.77 (18), p.4809-4822
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Spi-B-Mediated Silencing of Claudin-2 Promotes Early Dissemination of Lung Cancer Cells from Primary Tumors
- Ist Teil von
- Cancer research (Chicago, Ill.), 2017-09, Vol.77 (18), p.4809-4822
- Ort / Verlag
- United States: American Association for Cancer Research, Inc
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Dissociation from epithelial sheets and invasion through the surrounding stroma are critical early events during epithelial cancer metastasis. Here we find that a lymphocyte lineage-restricted transcription factor, Spi-B, is frequently expressed in human lung cancer tissues. The Spi-B-expressing cancer cells coexpressed vimentin but repressed E-cadherin and exhibited invasive behavior. Increased Spi-B expression was associated with tumor grade, lymphatic metastasis, and short overall survival. Mechanistically, Spi-B disrupted intercellular junctions and enhanced invasiveness by reconfiguring the chromatin structure of the tight junction gene claudin-2 ( ) and repressing its transcription. These data suggest that Spi-B participates in mesenchymal invasion, linking epithelial cancer metastasis with a lymphatic transcriptional program. .
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0008-5472eISSN: 1538-7445DOI: 10.1158/0008-5472.CAN-17-0020Titel-ID: cdi_proquest_miscellaneous_1924597015
- Format
- –
- Schlagworte
- Adenocarcinoma - genetics, Adenocarcinoma - metabolism, Adenocarcinoma - secondary, Animals, Apoptosis, Biomarkers, Tumor, Carcinoma, Lewis Lung - genetics, Carcinoma, Lewis Lung - metabolism, Carcinoma, Lewis Lung - secondary, Carcinoma, Non-Small-Cell Lung - genetics, Carcinoma, Non-Small-Cell Lung - metabolism, Carcinoma, Non-Small-Cell Lung - secondary, Carcinoma, Squamous Cell - genetics, Carcinoma, Squamous Cell - metabolism, Carcinoma, Squamous Cell - secondary, Cell Proliferation, Chromatin, Claudin-2 - genetics, Claudin-2 - metabolism, DNA-Binding Proteins - genetics, DNA-Binding Proteins - metabolism, E-cadherin, Gene Expression Regulation, Neoplastic, Humans, Intercellular Junctions, Invasiveness, Lung cancer, Lung Neoplasms - genetics, Lung Neoplasms - metabolism, Lung Neoplasms - pathology, Lymphocytes, Lymphocytes B, Mesenchyme, Metastases, Metastasis, Mice, Mice, Inbred C57BL, Mimicry, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, Small Cell Lung Carcinoma - genetics, Small Cell Lung Carcinoma - metabolism, Small Cell Lung Carcinoma - secondary, Stroma, Tissues, Transcription factors, Transcription Factors - genetics, Transcription Factors - metabolism, Tumor Cells, Cultured, Tumors, Vimentin, Xenograft Model Antitumor Assays