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Effectiveness of surgical treatment of severe macrocheilia in a patient with orofacial granulomatosis
Ist Teil von
Clinical and experimental dermatology, 2017-12, Vol.42 (8), p.887-889
Ort / Verlag
England: Oxford University Press
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Summary
Orofacial granulomatosis (OFG) is the term given to a group of diseases characterized by the presence of non‐necrotizing granulomatous inflammation affecting the soft tissues of the orofacial region. Treatment of OFG is often challenging and unsatisfactory. We report on a 32‐year‐old man with a 2‐year history of oedema and swelling of the upper lip without systemic symptoms. The history, clinical features and histopathological findings led to the diagnosis of cheilitis granulomatosa (CG), a disease included in the spectrum of OFG. The patient was treated with oral diaminodiphenyl sulfone (DDS) and clofazimine without success. Oral doxycycline led to a slight improvement of the disease. Because the volume of the upper lip was twice normal size, surgical reduction was performed, followed by administration of oral doxycycline for 3 months. This therapeutic approach led to complete remission, with no recurrence after 3 years.