Details

Autor(en) / Beteiligte

• Jan, Caroline
• Pessiglione, Mathias
• Tremblay, Léon
• Tandé, Dominique
• Hirsch, Etienne C.
• François, Chantal

Titel

Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeys

Ist Teil von

• The European journal of neuroscience, 2003-10, Vol.18 (7), p.2082-2086

Ort / Verlag

Oxford, UK: Blackwell Science, Ltd

Erscheinungsjahr

2003

Link zum Volltext

Quelle

EBSCOhost Psychology and Behavioral Sciences Collection

Beschreibungen/Notizen

• 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) intoxication in primates results in a heterogeneous loss of dopamine in the striatum, predominating in the dorsal and caudal parts of the structure, causing functional impairment that appears to be essentially motor and cognitive. The aim of the present study was to quantify the loss of dopamine in relation to the anatomo‐functional subdivisions of the striatum, and also of the pallidum and cortex of MPTP‐treated monkeys. A severe loss of dopaminergic innervation was observed in both the sensorimotor and associative territories of all these structures in MPTP‐treated monkeys. Comparatively, the limbic territories of all these structures were little affected. The preservation of dopaminergic innervation of the limbic part of cerebral structures may explain the preservation of motivational processes mediated by these limbic regions in MPTP‐treated monkeys.