Details

Autor(en) / Beteiligte

• Sepantafar, Mohammadmajid
• Maheronnaghsh, Reihan
• Mohammadi, Hossein
• Radmanesh, Fatemeh
• Hasani-sadrabadi, Mohammad Mahdi
• Ebrahimi, Marzieh
• Baharvand, Hossein

Titel

Engineered Hydrogels in Cancer Therapy and Diagnosis

Ist Teil von

• Trends in biotechnology (Regular ed.), 2017-11, Vol.35 (11), p.1074-1087

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Over the last decade, numerous investigations have attempted to clarify the intricacies of tumor development to propose effective approaches for cancer treatment. Thanks to the unique properties of hydrogels, researchers have made significant progress in tumor model reconstruction, tumor diagnosis, and associated therapies. Notably, hydrogel-based systems can be adjusted to respond to cancer-specific hallmarks and/or external stimuli. These well-known drug reservoirs can be used as smart carriers for multiple cargos, including both naked and nanoparticle-encapsulated chemotherapeutics, genes, and radioisotopes. Recent works have attempted to specialize hydrogels for cancer research; we comprehensively review this topic for the first time, synthesizing past results and defining paths for future work. Cancer is a complicated disease that necessitates high-throughput research. Animal models are not adaptable for cancer progression in humans. However, hydrogel-based reconstructive models can properly simulate the tumor microenvironment for cancer research. Smart hydrogel-based carriers and drug reservoirs could overcome the weaknesses of conventional therapy methods and provide targeted, localized, and adjusted delivery systems for genes, drugs, and radioisotopes. Hydrogels provide correlative and/or complementary combined therapies, such as chemotherapy and hyperthermia, chemotherapy and radiotherapy, and chemotherapy and gene therapy. Tumor imaging via a long-term modified nanomagnet-loaded hydrogel has demonstrated a reliable biodegradable imaging platform for tumor imaging and anticancer drug screening.