Details

Autor(en) / Beteiligte

• Doki, Noriko
• Suyama, Masahiro
• Sasajima, Satoshi
• Ota, Junko
• Igarashi, Aiko
• Mimura, Iyo
• Morita, Hidetoshi
• Fujioka, Yuki
• Sugiyama, Daisuke
• Nishikawa, Hiroyoshi
• Shimazu, Yutaka
• Suda, Wataru
• Takeshita, Kozue
• Atarashi, Koji
• Hattori, Masahira
• Sato, Eiichi
• Watakabe-Inamoto, Kyoko
• Yoshioka, Kosuke
• Najima, Yuho
• Kobayashi, Takeshi
• Kakihana, Kazuhiko
• Takahashi, Naoto
• Sakamaki, Hisashi
• Honda, Kenya
• Ohashi, Kazuteru

Titel

Clinical impact of pre-transplant gut microbial diversity on outcomes of allogeneic hematopoietic stem cell transplantation

Ist Teil von

• Annals of hematology, 2017-09, Vol.96 (9), p.1517-1523

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Post-transplant microbial diversity in the gastrointestinal tract is closely associated with clinical outcomes following allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, little is known about the impact of the fecal microbiota before allo-HSCT. We analyzed fecal samples approximately 2 weeks before conditioning among 107 allo-HSCT recipients between 2013 and 2015. Microbial analysis was performed using 16S rRNA gene sequencing. Operational taxonomic unit-based microbial diversity was estimated by calculating the Shannon index. Patients were classified into three groups based on the diversity index: low (<2), intermediate (2, 3), and high (>3) diversity (18 (16.8%), 48 (44.9%), and 41 (38.3%) patients, respectively). There were no significant differences in the 20-month overall survival, cumulative incidence of relapse, and non-relapse mortality among three groups. The cumulative incidence of grade II to IV acute graft-versus-host disease (aGVHD) was similar among the three groups (low 55.6%; intermediate 35.4%; high 48.8%, p  = 0.339, at day 100). Furthermore, we found no differences in the cumulative incidence of grade II to IV acute gastrointestinal GVHD among the three groups (low 38.9%; intermediate 21.3%; high 24.4%, p  = 0.778, at day 100). Regarding the composition of microbiota before allo-HSCT, aGVHD patients showed a significantly higher abundance of phylum Firmicutes ( p  < 0.01) and a lower tendency for Bacteroidetes ( p  = 0.106) than non-aGVHD patients. Maintenance of Bacteroidetes throughout allo-HSCT may be a strategy to prevent aGVHD.