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The Potential Impact of Radix Paeoniae Alba in Embryonic Development of Mice
Phytotherapy research, 2017-09, Vol.31 (9), p.1376-1383
Xu, Wei
Xu, Ling
Deng, Bin
Leng, Jing
Tang, Nong
Zhao, Li Chun
Zhou, Hong Hai
Zhao, Zhong Zhen
Yang, Zhi Jun
Xiao, Ting Ting
Tian, Xiao Ying
Ho, Alan H.M.
Chan, Nickie W.K.
Chow, Yeuk Lung
Chow, Chi Yi
Xu, Min
2017
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Xu, Wei
Xu, Ling
Deng, Bin
Leng, Jing
Tang, Nong
Zhao, Li Chun
Zhou, Hong Hai
Zhao, Zhong Zhen
Yang, Zhi Jun
Xiao, Ting Ting
Tian, Xiao Ying
Ho, Alan H.M.
Chan, Nickie W.K.
Chow, Yeuk Lung
Chow, Chi Yi
Xu, Min
Titel
The Potential Impact of Radix Paeoniae Alba in Embryonic Development of Mice
Ist Teil von
Phytotherapy research, 2017-09, Vol.31 (9), p.1376-1383
Ort / Verlag
England: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Although Radix Paeoniae Alba (RPA) has been ranked as one of the top 6 herbs used frequently to prevent and treat miscarriages clinically, there is no clear evidence regarding its safety in embryonic development. This study aims to evaluate the potential impacts of RPA on embryonic stem cells (ESCs) and pregnant mice. Cytotoxicity assays of the extract were performed in ESCs and 3T3 cells. Pregnant ICR mice were orally treated with RPA extracts at dosages of 0 (G1 group as negative controls), 2, 8 and 32 g/kg/day (G2, G3 and G4 groups) respectively from the gestation day (Gd) 6–15. On Gd 18, there was no significant difference in the IC50 values between ESCs and 3T3 cells (p > 0.05). There was no significant difference in the maternal and fetal evaluations among four groups (p > 0.05). Fetal IL‐2, IL‐2r, TNF‐α, TNF‐αr, IL‐4, IL‐4r, IL‐10r, IL‐17 and IL‐17r of G4 group were significantly lower than G1 group (p < 0.05). In conclusion, RPA at dosage of 32 g/kg/day (16‐folds of human daily dosage) did not cause adverse impact in cultured ESCs and pregnant mice. RPA might down‐regulate fetal Th1/Th2/Th17 cytokines and receptors maybe beneficial to embryonic survival and development. Copyright © 2017 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0951-418X
eISSN: 1099-1573
DOI: 10.1002/ptr.5864
Titel-ID: cdi_proquest_miscellaneous_1922507885
Format
–
Schlagworte
3T3 Cells
,
Animals
,
Cytokines
,
Cytokines - metabolism
,
Cytotoxicity
,
Dosage
,
Drugs, Chinese Herbal - pharmacology
,
Embryo cells
,
Embryogenesis
,
embryonic development
,
Embryonic Development - drug effects
,
Embryonic growth stage
,
embryonic safety
,
embryonic stem cell
,
Embryonic Stem Cells - drug effects
,
Embryos
,
Female
,
Fetus - drug effects
,
Fetuses
,
Gestation
,
Helper cells
,
Herbs
,
Interleukin 17
,
Interleukin 2
,
Interleukin 2 receptors
,
Interleukin 4
,
Lymphocytes T
,
Mice
,
Mice, Inbred ICR
,
mouse
,
Paeonia - chemistry
,
Pregnancy
,
Radix Paeoniae Alba
,
Receptors
,
Receptors, Cytokine - metabolism
,
Rodents
,
Stem cell transplantation
,
Stem cells
,
Th1/Th2/Th17 cytokine
,
Toxicity
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