Details

Autor(en) / Beteiligte

• Shaik, Muhammad Amin
• Venketasubramanian, Narayanaswamy
• Cheng, Ching-Yu
• Wong, Tien Yin
• Vrooman, Henri
• Ikram, Mohammad Kamran
• Hilal, Saima
• Chen, Christopher

Titel

Ankle brachial index, MRI markers and cognition: The Epidemiology of Dementia in Singapore study

Ist Teil von

• Atherosclerosis, 2017-08, Vol.263, p.272-277

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Previous studies showed an independent association of low ankle-brachial index (ABI) with cognitive impairment. However, the association between low ABI and cognition in the presence of both cerebrovascular disease (CeVD) and neurodegeneration is lacking. We aimed at investigating a) the association of low ABI with markers of CeVD and cortical thickness, and b) whether the association of low ABI with cognition is influenced by these markers. Data was drawn from the Epidemiology of Dementia In Singapore (EDIS) study where all participants (n = 832) underwent neuropsychological tests and 3T brain magnetic resonance imaging (MRI) to assess CeVD markers as well as cortical thicknesses. Cognitive function was expressed as a global composite z-score and domain-specific z-scores of a comprehensive neuropsychological battery. Multivariate analyses showed low ABI to be independently associated with intracranial stenosis [odds ratios (OR): 1.51; 95% confidence interval (CI):1.23–1.87] and lacunar infarcts [OR: 1.29; 95% CI: 1.06–1.57]. A low ABI was also independently associated with smaller cortical thickness globally [β: 0.09; 95% CI: 0.27–0.16] as well as with the limbic [β: 0.10; 95% CI: 0.03–0.17], temporal [β: 0.09; 95% CI: 0.02–0.15], parietal [β: 0.08; 95% CI: 0.02–0.15], and occipital [β: 0.09; 95% CI: 0.03–0.16] lobes. Low ABI was associated with worse performance in verbal memory [β: 0.06; 95% CI: 0.01–0.12], which became attenuated in the presence of MRI markers. A low ABI is associated with MRI markers, and affects cognition in the presence of CeVD and neurodegeneration. Atherosclerosis should be targeted as a potentially modifiable risk factor to prevent cognitive disorders. •Low ankle brachial index (ABI) is associated with both small and large vessel cerebrovascular diseases.•Low ABI is associated with neurodegeneration as measured by cortical thickness.•Low ABI is independently associated with reduced performance in verbal memory.•The presence of magnetic resonance imaging (MRI) markers influence the association between low ABI and cognition.