Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Genetic variability of interleukin-1 beta as prospective factor from developing post-traumatic stress disorder
Ist Teil von
Immunogenetics (New York), 2017-10, Vol.69 (10), p.703-708
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2017
Link zum Volltext
Quelle
SpringerLink (Online service)
Beschreibungen/Notizen
Individual susceptibility to post-traumatic stress disorder (PTSD) is conditioned by genetic factors, and association between this disorder and polymorphisms of several genes have been shown. The aim of this study was to explore a potential association between single nucleotide polymorphisms (SNP) of the IL-1β gene (
IL1B
) and PTSD. In genomic DNA samples of PTSD-affected and healthy subjects, the rs16944, rs1143634, rs2853550, rs1143643, and rs1143633 SNPs of
IL1B
gene have been genotyped. The results obtained demonstrated that
IL1B
rs1143633*C and rs16944*A minor allele frequency were significantly lower in patients than in controls. Our results confirm that
IL1B
rs1143633 and rs16944 SNPs are negatively associated with PTSD which allows us to consider them as protective variants for PTSD.
IL1B
rs1143633*C and rs16944*A minor allele frequencies and carriage rates are significantly lower in the PTSD patients as compared to the controls. These results may provide a base to conclude that above-mentioned alleles can be protective against PTSD, and
IL1B
gene can be involved in the pathogenesis of this disorder.