The lancet oncology, 2017-07, Vol.18 (7), p.e379-e393
2017
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- Autor(en) / Beteiligte
- Titel
- Radiotherapy in patients with HIV: current issues and review of the literature
- Ist Teil von
- The lancet oncology, 2017-07, Vol.18 (7), p.e379-e393
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Although the introduction of highly active antiretroviral therapy has radically improved the life expectancy of patients with HIV, HIV positivity is still considered a major barrier to oncological treatment for patients with cancer because of their worse prognosis and increased susceptibility to toxic effects compared with patients who are immunocompetent. The use of radiotherapy with or without chemotherapy, immunotherapy, or molecular targeted therapy is the standard of care for several cancers. These new drugs and substantial improvements in radiotherapy techniques, including intensity-modulated radiotherapy, image-guided radiotherapy, and stereotactic ablative radiotherapy, are optimising the feasibility of such anticancer treatments and are providing new opportunities for patients with cancer and HIV. In this Review, we discuss the role of radiotherapy, with or without chemotherapy or new drugs, in the treatment of cancer in patients with HIV, with a focus on the efficacy and tolerability of this approach on the basis of available evidence. Moreover, we analyse and discuss the biological basis of interactions between HIV and radiotherapy, evidence from preclinical studies, and immunomodulation by radiotherapy in the HIV setting.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1470-2045eISSN: 1474-5488DOI: 10.1016/S1470-2045(17)30440-0Titel-ID: cdi_proquest_miscellaneous_1916381349
- Format
- –
- Schlagworte
- Acquired immune deficiency syndrome, AIDS, Animals, Anti-HIV Agents - pharmacology, Anti-HIV Agents - therapeutic use, Antiretroviral Therapy, Highly Active, Cancer, Cancer therapies, Cell Line, Tumor, Chemotherapy, Health risk assessment, Highly active antiretroviral therapy, HIV, HIV Seropositivity - complications, HIV Seropositivity - drug therapy, Human immunodeficiency virus, Humans, Immunomodulation, Immunotherapy, Life span, Literature reviews, Neoplasms - complications, Neoplasms - radiotherapy, Oxidative Stress - drug effects, Oxidative Stress - radiation effects, Radiation therapy, Studies, Viral infections, Viruses