Physical chemistry chemical physics : PCCP, 2017-05, Vol.19 (21), p.13414-13418
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Unzipping and shearing DNA with electrophoresed nanoparticles in hydrogels
- Ist Teil von
- Physical chemistry chemical physics : PCCP, 2017-05, Vol.19 (21), p.13414-13418
- Ort / Verlag
- England
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We show electric control of unzipping and shearing dehybridization of a DNA duplex anchored to a hydrogel. Tensile force is applied by electrophoresing (25 V cm ) gold nanoparticles pulling the DNA duplex. The pulled DNA strand is gradually released from the hydrogel. The unzipping release rate is faster than shearing; for example, 3-fold for a 15 base pair duplex, which helps to design electrically driven DNA devices.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1463-9076eISSN: 1463-9084DOI: 10.1039/c7cp02214jTitel-ID: cdi_proquest_miscellaneous_1916378480
- Format
- –
- Schlagworte
- Acrylic Resins - chemistry, Deoxyribonucleic acid, Devices, DNA - chemistry, Electric control, Electrophoresis, Gold - chemistry, Hydrogels, Hydrogels - chemistry, Metal Nanoparticles - chemistry, Nanoparticles, Nucleic Acid Hybridization - drug effects, Physical chemistry, Shearing, Strands