Details

Autor(en) / Beteiligte

• Hong, Jeong-Ho
• Sohn, Sung-Il
• Kwak, Jaehyuk
• Yoo, Joonsang
• Chang, Hyuk Won
• Kwon, O-Ki
• Jung, Cheolkyu
• Chung, Inyoung
• Bae, Hee-Joon
• Lee, Ji Sung
• Han, Moon-Ku

Titel

Dose-Dependent Effect of Statin Pretreatment on Preventing the Periprocedural Complications of Carotid Artery Stenting

Ist Teil von

• Stroke (1970), 2017-07, Vol.48 (7), p.1890-1894

Ort / Verlag

United States: American Heart Association, Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• BACKGROUND AND PURPOSE—We investigated whether statin pretreatment can dose dependently reduce periprocedural complications in patients undergoing carotid artery stenting because of symptomatic carotid artery stenosis. METHODS—We enrolled a consecutive series of 397 symptomatic carotid artery stenosis (≥50% stenosis on conventional angiography) treated with carotid artery stenting at 2 tertiary university hospitals over a decade. Definition of periprocedural complications included any stroke, myocardial infarction, and death within 1 month after or during the procedure. Statin pretreatment was divided into 3 categories according to the atorvastatin equivalent dosenone (n=158; 39.8%), standard dose (<40 mg of atorvastatin, n=155; 39.0%), and high dose (≥40 mg; n=84; 21.2%). A multivariable logistic regression analysis with the generalized estimating equation method was used to investigate independent factors in periprocedural complications. RESULTS—The patients’ mean age was 68.7 years (81.6% men). The periprocedural complication rates across the 3 categories of statin use were 12.0%, 4.5%, and 1.2%. After adjustment, a change in the atorvastatin dose category was associated with reduction in the odds of periprocedural complications for each change in dose category (standard-dose statinodds ratio, 0.24; 95% confidence interval, 0.07−0.81; high-dose statinodds ratio, 0.11; 95% confidence interval, 0.01−0.96; P for trend=0.01). Administration of antiplatelet drugs was also an independent factor in periprocedural complications (OR, 0.18; 95% CI, 0.05−0.69). CONCLUSIONS—This study shows that statin pretreatment may reduce the incidence of periprocedural complications dose dependently in patients with symptomatic carotid artery stenting.