Trends in cell biology, 2017-09, Vol.27 (9), p.623-632
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Using Force to Punch Holes: Mechanics of Contractile Nanomachines
- Ist Teil von
- Trends in cell biology, 2017-09, Vol.27 (9), p.623-632
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Using physical force to translocate macromolecules across a membrane has the advantage of being a universal solution independent of the properties of the target membrane. However, physically punching a stiff membrane is not a trivial task and three things are necessary for success: a sharp tip, a source of energy, and the ability to strongly bind to the target. In this review we describe the basic mechanism of membrane puncturing by contractile nanomachines with a focus on the T4 phage, R-type pyocin, and the bacterial Type VI secretion system (T6SS) based on recent studies of the structures and dynamics of their assembly.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0962-8924eISSN: 1879-3088DOI: 10.1016/j.tcb.2017.05.003Titel-ID: cdi_proquest_miscellaneous_1909165110
- Format
- –
- Schlagworte
- Bacteria, Bacterial Proteins - metabolism, bacterial toxins, Bacteriophage T4 - metabolism, contractile bacteriophages, Contractility, Dynamic structural analysis, Macromolecules, membrane, Membranes, Membranes - metabolism, Nanomaterials, Pathology, Phages, Piercing, protein translocation, Pyocins - metabolism, Secretion, structure and dynamics, Studies, Success factors, Type VI secretion system, Type VI Secretion Systems - metabolism