Details

Autor(en) / Beteiligte

• Lee, Da Hyon
• Park, Taek Kyu
• Seong, Choong Sil
• Gwag, Hye Bin
• Lim, A. Young
• Oh, Min Seok
• Cho, Sung Woo
• Yang, Jeong Hoon
• Song, Young Bin
• Hahn, Joo-Yong
• Choi, Jin-Ho
• Lee, Sang Hoon
• Gwon, Hyeon-Cheol
• Choi, Seung-Hyuk

Titel

Gender differences in long-term clinical outcomes and prognostic factors in patients with vasospastic angina

Ist Teil von

• International journal of cardiology, 2017-12, Vol.249, p.6-11

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background Men are more likely to suffer from vasospastic angina (VSA) than women; however, gender differences in the long-term prognosis of VSA patients have not been fully elucidated. We sought to investigate clinical outcomes and predictive factors of VSA patients according to gender. Methods A total of 986 patients (838 men and 148 women) with a positive result on intracoronary ergonovine provocation test between January 2003 and December 2014 were analyzed. The primary outcome was major adverse cardiac events (MACE), defined as a composite of cardiac death, acute myocardial infarction, revascularization, or rehospitalization due to recurrent angina. Results Women were younger and showed a lower prevalence of smoking or fixed coronary stenosis than men. The risk for MACE was similar between male and female patients (hazard ratio [HR], 0.95; 95% confidence interval [CI], 0.65–1.39; p = 0.79). In multivariable prediction models for MACE, high-sensitivity C-reactive protein (hs-CRP) level was a significant predictor of MACE in male patients (HR, 1.95; 95% CI, 1.25–3.06; p = 0.003), but there was no significant predictor in female patients. There was a significant interaction between hs-CRP level and MACE rate across genders (interaction p = 0.02). Conclusions Long-term clinical outcome was not different between genders. Hs-CRP was an important predictor of long-term clinical outcomes in male patients with VSA, but not in female patients.