Details

Autor(en) / Beteiligte

• Dudele, A
• Hougaard, K S
• Kjølby, M
• Hokland, M
• Winther, G
• Elfving, B
• Wegener, G
• Nielsen, A L
• Larsen, A
• Nøhr, M K
• Pedersen, S B
• Wang, T
• Lund, S

Titel

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner

Ist Teil von

• International Journal of Obesity, 2017-09, Vol.41 (9), p.1420-1426

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• The current world-wide obesity epidemic partially results from a vicious circle whereby maternal obesity during pregnancy predisposes the offspring for accelerated weight gain and development of metabolic syndrome. Here we investigate whether low-grade inflammation, characteristic of the obese state, provides a causal role for this disastrous fetal programming in mice. We exposed pregnant and lactating C57BL/6JBom female mice to either high-fat diet (HFD), or continuous infusion of lipopolysaccharide (LPS), a potent trigger of innate immunity, and studied offspring phenotypes. Both maternal LPS or HFD treatments rendered the offspring hyperphagic and inept of coping with a HFD challenge during adulthood, increasing their adiposity and weight gain. The metabolic effects were more pronounced in female offspring, while exposed male offspring mounted a larger inflammatory response to HFD at adulthood. This supports our hypothesis and highlights the programming potential of inflammation in obese pregnancies.