Details

Autor(en) / Beteiligte

• Nishimatsu, Kayo
• Nakamoto, Yuji
• Miyake, Kanae K
• Ishimori, Takayoshi
• Kanao, Shotaro
• Toi, Masakazu
• Togashi, Kaori

Titel

Higher breast cancer conspicuity on dbPET compared to WB-PET/CT

Ist Teil von

• European journal of radiology, 2017-05, Vol.90, p.138-145

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• Abstract Objectives The purpose of this study was to evaluate lesion detectability of a dedicated breast positron-emission tomography (dbPET) scanner for breast cancers with an updated reconstruction mode, comparing it to whole-body positron-emission tomography/computed tomography (WB-PET/CT). Materials and methods A total of 179 histologically-proven breast cancer lesions in 150 females who underwent both WB-PET/CT and dbPET with18 F-fluorodeoxyglucose were retrospectively analyzed. The patient/breast/lesion-based sensitivities based on visual analysis were compared between dbPET and WB-PET/CT. For lesions visible on both PET images, SUVmax values of the tumors were measured, and tumor-to-background ratios (T/B ratios) of SUVmax were compared between the two scans. Subgroup analyses according to clinical tumor stage, histopathology and histological grade were also performed. Results Patient/breast/lesion-based sensitivities were 95%, 95%, and 92%, respectively, for dbPET, and 95%, 94%, and 88%, respectively, for WB-PET/CT. Mean ± standard deviation SUVmax values of FDG-avid tumors were 13.0 ± 9.7 on dbPET and 6.4 ± 4.8 on WB-PET. T/B ratios were also significantly higher in dbPET than in WB-PET/CT (8.1 ± 7.1 vs. 5.1 ± 4.5). In the subgroup analysis, no significant differences in sensitivities between dbPET and WB-PET/CT were found. However, T/B ratios of dbPET were significantly higher than those of WB-PET/CT in cT1c, cT2, cT3, invasive cancer, invasive carcinoma of no special type, mucinous carcinoma and Grades 1–3. Conclusion No significant differences in sensitivities were identified between dbPET using an updated reconstruction mode and WB-PET/CT; however, T/B ratios of dbPET were significantly higher than those of WB-PET/CT, indicating higher tumor conspicuity on dbPET.