Molecular medicine reports, 2017-08, Vol.16 (2), p.1537-1543
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Acerogenin C from Acer nikoense exhibits a neuroprotective effect in mouse hippocampal HT22 cell lines through the upregulation of Nrf-2/HO-1 signaling pathways
- Ist Teil von
- Molecular medicine reports, 2017-08, Vol.16 (2), p.1537-1543
- Ort / Verlag
- Greece: D.A. Spandidos
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Oxidative stress contributes to neuronal death in the brain, and neuronal death can cause aging or neurodegenerative disease. Heme oxygenase 1 (HO-1) serves a vital role in the regulation of biological reactions, including oxidative stress associated with reactive oxygen species. In the present study, acerogenin C isolated from the Aceraceae plant Acer nikoense, which is used as a Japanese folk medicine for hepatic disorders and eye diseases. However, there have been no studies on the mechanisms underlying the antineurodegenerative biological activities of acerogenin C. In the present study, acerogenin C demonstrated neuroprotective action against glutamate-induced cell death in hippocampal HT22 cells through the upregulation of HO-1 expression. These effects were also associated with nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and the activation of phosphoinositide 3-kinase/protein kinase B. Taken together of the efficacy researches, this study determines that the Nrf2/HO-1 pathways denotes a biological mark and that acerogenin C might contribute to prevention of neurodegenerative disorders.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1791-2997eISSN: 1791-3004DOI: 10.3892/mmr.2017.6682Titel-ID: cdi_proquest_miscellaneous_1906466323
- Format
- –
- Schlagworte
- Acer - chemistry, acerogenin C, AKT protein, Alzheimer's disease, Animals, Antioxidants, Apoptosis, Care and treatment, Cell culture, Cell death, Cell Death - drug effects, Cell Line, Cell lines, Cell Nucleus - drug effects, Cell Nucleus - metabolism, Chemical properties, Diagnosis, Enzymes, Eye, Eye diseases, Fluorides, GA-binding protein, Genetic aspects, Glutamate, Glutamic Acid - toxicity, Heme, heme oxygenase 1, Heme Oxygenase-1 - genetics, Heme Oxygenase-1 - metabolism, Hippocampus, Hippocampus - cytology, HT22 cells, Liver diseases, Medicinal plants, Mice, Neurodegenerative diseases, Neuroprotection, neuroprotective action, Neuroprotective Agents - chemistry, Neuroprotective Agents - pharmacology, Neurotoxicity, NF-E2-Related Factor 2 - metabolism, nuclear factor erythroid 2-related factor 2, Nuclear transport, Oxidative stress, Oxygenase, Phenyl Ethers - chemistry, Phenyl Ethers - pharmacology, Phosphatidylinositol 3-Kinases - metabolism, Protein expression, Protein Transport - drug effects, Proteins, Proto-Oncogene Proteins c-akt - metabolism, Reactive oxygen species, Reactive Oxygen Species - metabolism, RNA, Messenger - genetics, RNA, Messenger - metabolism, Rodents, Signal Transduction - drug effects, Up-regulation, Up-Regulation - drug effects