Details

Autor(en) / Beteiligte

• Zhang, Yan-bo
• Ding, Jian-xun
• Xu, Wei-guo
• Wu, Jie
• Chang, Fei
• Zhuang, Xiu-li
• Chen, Xue-si
• Wang, Jin-cheng

Titel

Biodegradable Thermogel as Culture Matrix of Bone Marrow Mesenchymal Stem Cells for Potential Cartilage Tissue Engineering

Ist Teil von

• Chinese journal of polymer science, 2014-12, Vol.32 (12), p.1590-1601

Ort / Verlag

Heidelberg: Chinese Chemical Society and Institute of Chemistry, CAS

Erscheinungsjahr

2014

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Poly（lactide-co-glycolide）-poly（ethylene glycol）-poly（lactide-co-glycolide）（PLGA-PEG-PLGA） triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions, and formed hydrogels as the increase of temperature at relatively high concentrations（〉 15 wt%）. The favorable degradability of the hydrogel was confirmed by in vitro and in vivo degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEGPLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.