Details

Autor(en) / Beteiligte

• Zhu, Xinju
• Shen, Xiao-Jing
• Tian, Zi-Yao
• Lu, Shuai
• Tian, Lu-Lu
• Liu, Wen-Bo
• Song, Bing
• Hao, Xin-Qi

Titel

Rhodium-Catalyzed Direct Bis-cyanation of Arylimidazo[1,2-α]pyridine via Double C–H Activation

Ist Teil von

• Journal of organic chemistry, 2017-06, Vol.82 (12), p.6022-6031

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An efficient Cp*Rh­(III)-catalyzed selective bis-cyanation of aryl­imidazo­[1,2-α]­pyridines with N-cyano-N-phenyl-p-methyl­benzene­sulfonamide via N-directed ortho double C–H activation has been developed. The reaction proceeds with broad functional group tolerance to furnish various cyanated imidazo­pyridines in high yields. The current methodology exhibits unique characteristics, including high bis-cyanation selectivity, operational convenience, and gram-scale production.