Details

Autor(en) / Beteiligte

• Zhang, Jianjun
• Fujimoto, Junya
• Zhang, Jianhua
• Wedge, David C.
• Song, Xingzhi
• Zhang, Jiexin
• Seth, Sahil
• Chow, Chi-Wan
• Cao, Yu
• Gumbs, Curtis
• Gold, Kathryn A.
• Kalhor, Neda
• Little, Latasha
• Mahadeshwar, Harshad
• Moran, Cesar
• Protopopov, Alexei
• Sun, Huandong
• Tang, Jiabin
• Wu, Xifeng
• Ye, Yuanqing
• William, William N.
• Lee, J. Jack
• Heymach, John V.
• Hong, Waun Ki
• Swisher, Stephen
• Wistuba, Ignacio I.
• Futreal, P. Andrew

Titel

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

Ist Teil von

• Science (American Association for the Advancement of Science), 2014-10, Vol.346 (6206), p.256-260

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Cancers are composed of populations of cells with distinct molecular and phenotypic features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not been well studied. We applied multiregion whole-exome sequencing (WES) on 11 localized lung adenocarcinomas. All tumors showed clear evidence of ITH. On average, 76% of all mutations and 20 out of 21 known cancer gene mutations were identified in all regions of individual tumors, which suggested that single-region sequencing may be adequate to identify the majority of known cancer gene mutations in localized lung adenocarcinomas. With a median follow-up of 21 months after surgery, three patients have relapsed, and all three patients had significantly larger fractions of subclonal mutations in their primary tumors than patients without relapse. These data indicate that a larger subclonal mutation fraction may be associated with increased likelihood of postsurgical relapse in patients with localized lung adenocarcinomas.