Details

Autor(en) / Beteiligte

• Johana Baños-Hernández, Christian
• Eduardo Navarro Zarza, José
• Parra Rojas, Isela
• Vázquez Villamar, Mirna
• Ramón Padilla-Gutiérrez, Jorge
• Valle, Yeminia
• Reyes-Castillo, Zyanya
• Magdalena Torres-Carrillo, Nora
• García-Arellano, Samuel
• Michele Brennan-Bourdon, Lorena
• Francisco Muñoz-Valle, José

Titel

PADI4 polymorphisms and the functional haplotype are associated with increased rheumatoid arthritis susceptibility: a replication study in a Southern Mexican population

Ist Teil von

• Human immunology, 2017-09, Vol.78 (9), p.553-558

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Rheumatoid arthritis (RA) is a common autoimmune disease with a complex genetic background. The peptidyl arginine deiminase type IV ( PADI4 ) gene has been associated with RA susceptibility in several populations. We addressed the relationship between three exonic PADI4 gene single nucleotide polymorphisms (SNPs) PADI4_89 (rs11203366), PADI4_90 (rs11203367) and PADI4_92 (rs874881) and related haplotypes with RA in a population from Southern México. This study included 200 RA patients and 200 control subjects. The SNPs were evaluated using the polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) technique, and antibodies to cyclic citrullinated peptides (anti-CCP) were measured by enzyme-linked immunosorbent assay (ELISA). In this population, the minor alleles of PADI4_ 89∗G, PADI4 _90∗T and PADI4 _92∗G gene polymorphisms were associated with RA susceptibility (OR= 1.34, p =0.04; OR=1.35, p = 0.03; OR= 1.34, p =0.04; respectively). The GTG haplotype was also significantly associated with RA (OR=2.27 95%CI=1.18-4.41; p=0.008), but did not show association with levels of anti-CCP antibodies and clinical parameters. In conclusion, our replication study in a Southern Mexican population suggests that PADI4 individual polymorphisms and the related susceptibility haplotype (GTG) are also genetic risk markers for RA.