Journal of dermatological science, 2017-10, Vol.88 (1), p.126-133
2017
Details
- Autor(en) / Beteiligte
- Titel
- A synthetic peptide blocking TRPV1 activation inhibits UV-induced skin responses
- Ist Teil von
- Journal of dermatological science, 2017-10, Vol.88 (1), p.126-133
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 was devised. • TIP inhibited UV-induced MMP-1, IL-6, and TNF-α in HaCaT in vitro. • TIP inhibited UV-induced responses in mouse and human skin in vivo.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0923-1811eISSN: 1873-569XDOI: 10.1016/j.jdermsci.2017.05.009Titel-ID: cdi_proquest_miscellaneous_1903437046
- Format
- –
- Schlagworte
- Adult, Animals, Back, Biopsy, Calcium - metabolism, Capsaicin - pharmacology, Cell Line, Collagenases - metabolism, Dermatology, Disease Models, Animal, Erythema - drug therapy, Erythema - etiology, Female, Healthy Volunteers, Humans, Interleukin-6 - metabolism, Interleukin-8 - metabolism, Keratinocytes - drug effects, Keratinocytes - metabolism, Keratinocytes - radiation effects, Male, Matrix metalloproteinases, Mice, Mice, Hairless, Peptides - chemical synthesis, Peptides - pharmacology, Peptides - therapeutic use, Phosphorylation, Pro-inflammatory cytokines, Skin - drug effects, Skin - metabolism, Skin - pathology, Skin - radiation effects, Skin Aging - drug effects, Skin Aging - pathology, Threonine - metabolism, Transient receptor potential vanilloid 1, TRPV Cation Channels - antagonists & inhibitors, TRPV Cation Channels - metabolism, Tumor Necrosis Factor-alpha - metabolism, Ultraviolet, Ultraviolet Rays - adverse effects