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Vitamin D3 Alters the Expression of Toll‐like Receptors in Peripheral Blood Mononuclear Cells of Patients With Systemic Lupus Erythematosus
Journal of cellular biochemistry, 2017-12, Vol.118 (12), p.4831-4835
Yazdanpanah, Esmaeil
Mahmoudi, Mahmoud
Sahebari, Maryam
Rezaieyazdi, Zahra
Esmaeili, Seyed‐Alireza
Tabasi, Nafiseh
Jaberi, Soheila
Sahebkar, Amirhossein
Rastin, Maryam
2017
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Yazdanpanah, Esmaeil
Mahmoudi, Mahmoud
Sahebari, Maryam
Rezaieyazdi, Zahra
Esmaeili, Seyed‐Alireza
Tabasi, Nafiseh
Jaberi, Soheila
Sahebkar, Amirhossein
Rastin, Maryam
Titel
Vitamin D3 Alters the Expression of Toll‐like Receptors in Peripheral Blood Mononuclear Cells of Patients With Systemic Lupus Erythematosus
Ist Teil von
Journal of cellular biochemistry, 2017-12, Vol.118 (12), p.4831-4835
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Quelle
MEDLINE
Beschreibungen/Notizen
ABSTRACT Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of inflammatory cytokines and autoreactive antibodies due to the loss of immune tolerance. Recognition of self‐nucleic acids by intracellular Toll‐like receptors (TLRs) can overactivate immune responses and this abnormal activation of TLRs contributes to the pathogenesis of the disease. In recent years, anti‐inflammatory and immunomodulatory effects of 1,25‐dihydroxyvitamin D3 (VitD3) on the immune system has received particular attention. The present study investigated the effects of vitamin D3 on the expression of TLR3, TLR7, and TLR9 in SLE patients. Study participants included 20 SLE patients and 20 age‐ and sex‐matched healthy controls. Peripheral blood mononuclear cells (PBMCs) were isolated and cultured in the presence or absence of vitamin D3 (50 nM). Then RNA was extracted, cDNA was synthesized and gene expression levels of TLR3, TLR7, and TLR9 were assessed using real‐time PCR. Up‐regulated expression levels of TLR7 and TLR9 were observed in the PBMCs of SLE patients in comparison with controls. Culturing PBMCs with vitamin D3 significantly down‐regulated the expression of TLR3 (8.86 ± 4.2 for SLE patients vs. 45.34 ± 18.6 for control; P = 0.03), TLR7 (17.91 ± 7.7 for SLE patients vs. 242.37 ± 89.6 for controls; P = 0.0001) and TLR9 (4.67 ± 1.9 for SLE patients vs. 8.9 ± 1.5 for controls; P = 0.007) in SLE patients in comparison with healthy controls. The results of the current study suggest that vitamin D3 could exert some of its immunomodulatory effects in SLE patients via affecting the expression levels of some TLRs. J. Cell. Biochem. 118: 4831–4835, 2017. © 2017 Wiley Periodicals, Inc. The results of the current study suggest that vitamin D3 could exert some of its immunomodulatory effects in SLE patients via affecting the expression levels of some TLRs.
Sprache
Englisch
Identifikatoren
ISSN: 0730-2312
eISSN: 1097-4644
DOI: 10.1002/jcb.26155
Titel-ID: cdi_proquest_miscellaneous_1903166276
Format
–
Schlagworte
Adult
,
Antibodies
,
Autoimmune diseases
,
Calcitriol
,
Cells, Cultured
,
Cholecalciferol - pharmacology
,
Chronic conditions
,
Cytokines
,
Female
,
Gene expression
,
Gene Expression Regulation - drug effects
,
Humans
,
Immune response
,
Immune system
,
Immunological tolerance
,
Immunomodulation
,
Inflammation
,
Leukocytes (mononuclear)
,
Leukocytes, Mononuclear - metabolism
,
Leukocytes, Mononuclear - pathology
,
Lupus
,
Lupus Erythematosus, Systemic - metabolism
,
Lupus Erythematosus, Systemic - pathology
,
Male
,
Middle Aged
,
Nucleic acids
,
Pathogenesis
,
Patients
,
PERIPHERAL BLOOD MONONUCLEAR CELLS
,
Proteins
,
REAL‐TIME PCR
,
Receptors
,
Ribonucleic acid
,
RNA
,
SYSTEMIC LUPUS ERYTHEMATOSUS
,
T cell receptors
,
TLR3 protein
,
TLR7 protein
,
TLR9 protein
,
TOLL LIKE RECEPTORS
,
Toll-Like Receptors - biosynthesis
,
VITAMIN D3
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