Details

Autor(en) / Beteiligte

• Ahn, Sung Soo
• Song, Jason Jungsik
• Park, Yong‐Beom
• Lee, Sang‐Won

Titel

Malignancies in Korean patients with immunoglobulin G4‐related disease

Ist Teil von

• International journal of rheumatic diseases, 2017-08, Vol.20 (8), p.1028-1035

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Aim Several studies have implicated increased risk of malignancy in patients with immunoglobulin G4‐related disease (IgG4‐RD). Hence, we first evaluated the risk and the type of malignancy in Korean IgG4‐RD patients. Method Clinical and laboratory results of patients fulfilling the comprehensive diagnostic criteria for IgG4‐RD were retrospectively collected between January 2006 and November 2015. One hundred and eighteen patients were included, and 35 were classified as having definite, 83 as possible/probable IgG4‐RD. We compared baseline clinical and laboratory variables between patients with definite and those with possible/probable IgG4‐RD and calculated standardized incidence ratios (SIRs) for malignancies. Results The median age was 60 years old and 91 patients (77.1%) were male. Malignancies were found in 12 of 118 patients (10.1%), and lymphoma (4, 25.0%) was the most frequent malignancy related to IgG4‐RD. Definite IgG4‐RD patients had higher serum IgG levels and frequent multiple organ involvement. The overall incidence of malignancy was increased in patients with IgG4‐RD compared to the general population (SIR 23.08 [95% CI 11.92–40.31]), and the overall risk of SIRs was highest in non‐Hodgkin lymphoma (SIR 400.00 [95% CI 109.00–1024.00]). Conclusion Our data showed that increased risk of malignancy, especially lymphomas, was observed in Korean IgG4‐RD patients.