Details

Autor(en) / Beteiligte

• Ramallal, Raúl
• Toledo, Estefanía
• Martínez, J. Alfredo
• Shivappa, Nitin
• Hébert, James R.
• Martínez‐González, Miguel A.
• Ruiz‐Canela, Miguel

Titel

Inflammatory potential of diet, weight gain, and incidence of overweight/obesity: The SUN cohort

Ist Teil von

• Obesity (Silver Spring, Md.), 2017-06, Vol.25 (6), p.997-1005

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Objective This study prospectively assessed the association of the inflammatory potential of a diet using the dietary inflammatory index (DII) with average yearly weight changes and incident overweight/obesity. Methods Seven thousand and twenty‐seven university graduates with body mass index <25 from the Seguimiento Universidad de Navarra (SUN) cohort were followed up during a median of 8.1 years. The DII, a validated tool based on scientific evidence to appraise the relationship between dietary parameters and inflammatory biomarkers, was used. A validated food‐frequency questionnaire was used to assess intake of total energy, food, and nutrients, from which DII scores were calculated at baseline and after 10 years of follow‐up. Results After a median follow‐up of 8.1 years, 1,433 incident cases of overweight or obesity were observed. Hazard ratios for overweight/obesity were calculated, including multivariable time‐dependent Cox regression models with repeated measures of diet. The hazard ratio for subjects in the highest quartile (most pro‐inflammatory diet) was 1.32 (95% confidence interval 1.08‐1.60) compared with participants in the lowest quartile (most anti‐inflammatory diet), with a significant linear dose‐response relationship (P = 0.004). Consistently, increases in average yearly weight gains were significantly associated with proinflammatory diets. Conclusions A proinflammatory diet was significantly associated with a higher annual weight gain and higher risk of developing new‐onset overweight or obesity.