Details

Autor(en) / Beteiligte

• Galván‐Chacón, Víctor Pablo
• Habibovic, Pamela

Titel

Deconvoluting the Bioactivity of Calcium Phosphate‐Based Bone Graft Substitutes: Strategies to Understand the Role of Individual Material Properties

Ist Teil von

• Advanced healthcare materials, 2017-07, Vol.6 (13), p.n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• Calcium phosphate (CaP)‐based ceramics are the most widely applied synthetic biomaterials for repair and regeneration of damaged and diseased bone. CaP bioactivity is regulated by a set of largely intertwined physico‐chemical and structural properties, such as the surface microstructure, surface energy, porosity, chemical composition, crystallinity and stiffness. Unravelling the role of each individual property in the interaction between the biomaterial and the biological system is a prerequisite for evolving from a trial‐and‐error approach to a design‐driven approach in the development of new functional biomaterials. This progress report critically reviews various strategies developed to decouple the roles of the individual material properties in the biological performance of CaP ceramics. It furthermore emphasizes on the importance of a comprehensive and adequate material characterization that is needed to enhance our knowledge of the property‐function relationship of biomaterials used in bone regeneration, and in regenerative medicine in general. Calcium phosphate ceramics are the most widely applied synthetic bone graft substitutes. Their biological performance is regulated by a set of largely intertwined material properties. To evolve from a production process‐driven to a design‐driven development of these biomaterials, it is necessary to unravel the role of each individual property in their interaction with a biological system. For this, strategies to decouple the effects of the individual properties are required.