Immunology letters, 2017-08, Vol.188, p.1-8
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Ursodeoxycholic acid attenuates experimental autoimmune arthritis by targeting Th17 and inducing pAMPK and transcriptional corepressor SMILE
- Ist Teil von
- Immunology letters, 2017-08, Vol.188, p.1-8
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2017
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Highlights • Ursodeoxycholic acid (UDCA) reveals therapeutic effect in animal model for rheumatoid arthritis. • UDCA induced the activation of AMP-activated protein kinase (AMPK) and p38 in mouse CD4+ T cells. • UDCA suppressed T helper (Th)17 differentiation through upregulation of small heterodimer partner interacting leucine zipper protein (SMILE) and transcriptional activity of peroxisome proliferator-activated receptor (PPAR)γ.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0165-2478eISSN: 1879-0542DOI: 10.1016/j.imlet.2017.05.011Titel-ID: cdi_proquest_miscellaneous_1902481767
- Format
- –
- Schlagworte
- Allergy and Immunology, AMP-Activated Protein Kinases - metabolism, AMPK, Animals, Arthritis, Experimental - diagnosis, Arthritis, Experimental - drug therapy, Arthritis, Experimental - immunology, Arthritis, Experimental - metabolism, Autoimmune Diseases - diagnosis, Autoimmune Diseases - drug therapy, Autoimmune Diseases - immunology, Autoimmune Diseases - metabolism, Basic-Leucine Zipper Transcription Factors - metabolism, Biomarkers, Cytokines - metabolism, Disease Models, Animal, Humans, Lipid Metabolism, Lipids - blood, Male, Mice, PPARγ, Rheumatoid arthritis (RA), SMILE, Th17 cell, Th17 Cells - immunology, Th17 Cells - metabolism, Ursodeoxycholic acid (UDCA), Ursodeoxycholic Acid - pharmacology