Details

Autor(en) / Beteiligte

• Morais, Jennifer Beatriz Silva
• Severo, Juliana Soares
• de Alencar, Geórgia Rosa Reis
• de Oliveira, Ana Raquel Soares
• Cruz, Kyria Jayanne Clímaco
• Marreiro, Dilina do Nascimento
• Freitas, Betânia de Jesus e Silva de Almendra
• de Carvalho, Cecília Maria Resende
• Martins, Maria do Carmo de Carvalho e
• Frota, Karoline de Macedo Gonçalves

Titel

Effect of Magnesium Supplementation on Insulin Resistance in Humans: a Systematic Review

Ist Teil von

• Nutrition (Burbank, Los Angeles County, Calif.), 2017-06, Vol.38, p.54-60

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Objectives Recent studies have demonstrated a role of minerals in glucose metabolism disorders in humans. Magnesium, in particular, is an extensively studied mineral that has been shown to function in the management of hyperglycemia, hyperinsulinemia, and insulin resistance action. The aim of this study was to investigate the effect of magnesium supplementation on insulin resistance in humans via systematic review of the available clinical trials. Methods This review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. A survey was conducted for selecting clinical trials related to the effects of this mineral in insulin sensitivity using the following databases: PubMed, SciVerse Scopus, ScienceDirect, and SciVerse Cochrane. Results After the selection process, 12 articles were identified as eligible for this review, with different clinical conditions without restriction of sex, age, ethnicity, and differential dosing/shape of magnesium. The results of eight clinical trials have shown that supplementation with magnesium influences serum fasting glucose concentrations, and five trials determined an effect on fasting insulin levels. The results of seven studies have shown that mineral supplementation reduced homeostasis model assessment for insulin resistance values. Conclusions The data of this systematic review provide evidence on the benefits of magnesium supplementation in reducing insulin resistance in subjects with hypomagnesemia presenting insulin resistance. However, new intervention studies are needed to elucidate the role of the nutrient in protection against this metabolic disorder, as well as the standardization of the type, dose, and time of magnesium supplementation.