Details

Autor(en) / Beteiligte

• Hu, Yuan-Qiang
• Xu, Zhi
• Zhang, Shu
• Wu, Xiang
• Ding, Jun-Wei
• Lv, Zao-Sheng
• Feng, Lian-Shun

Titel

Recent developments of coumarin-containing derivatives and their anti-tubercular activity

Ist Teil von

• European journal of medicinal chemistry, 2017-08, Vol.136, p.122-130

Ort / Verlag

France: Elsevier Masson SAS

Erscheinungsjahr

2017

Quelle

ScienceDirect

Beschreibungen/Notizen

• Tuberculosis (TB) is a lift-threatening chronic deadliest infectious disease caused predominantly by Mycobacterium tuberculosis (MTB) which affects primarily the lungs (pulmonary TB) apart from other vital organs. The emergence of drug-resistant TB (DR-TB), multidrug-resistant TB (MDR-TB), extensively drug-resistant TB (XDR-TB) and the recently cases of totally drug resistant (TDR) towards currently accessible standard drugs was increased up to alarming level in the recent decades. In pursuit of searching new anti-TB agents, numerous of derivatives have been synthesized and screened for their anti-TB activity. Coumarins are one of the most important classes of natural products that exhibited various biological activities, and their derivatives regarded as a new class of effective anti-TB candidates owing to their potential anti-TB activity. Thus, coumarin skeleton has attracted great interest in the development of new anti-TB agents. This review outlines the advances in the application of coumarin-containing derivatives as anti-TB agents and the critical aspects of design and structure-activity relationship of these derivatives. This review outlines the advances in the application of coumarin-containing derivatives as anti-TB agents and the critical aspects of design and structure-activity relationship of these derivatives. [Display omitted] •Coumarins are one of the most important classes of natural products that exhibited various biological activities, .•and their derivatives regarded as a new class of effective anti-TB candidates owing to their potential anti-TB activity.•Thus, coumarin skeleton has attracted great interest in the development of new anti-TB agents.