Details

Autor(en) / Beteiligte

• Zelicha, Hila
• Schwarzfuchs, Dan
• Shelef, Ilan
• Gepner, Yftach
• Tsaban, Gal
• Tene, Lilac
• Yaskolka Meir, Anat
• Bilitzky, Avital
• Komy, Oded
• Cohen, Noa
• Bril, Nitzan
• Rein, Michal
• Serfaty, Dana
• Kenigsbuch, Shira
• Chassidim, Yoash
• Sarusi, Benjamin
• Thiery, Joachim
• Ceglarek, Uta
• Stumvoll, Michael
• Blüher, Matthias
• Haviv, Yosef S
• Stampfer, Meir J
• Rudich, Assaf
• Shai, Iris

Titel

Changes of renal sinus fat and renal parenchymal fat during an 18-month randomized weight loss trial

Ist Teil von

• Clinical nutrition (Edinburgh, Scotland), 2018-08, Vol.37 (4), p.1145-1153

Ort / Verlag

England

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Summary Background & aims Data regarding the role of kidney adiposity, its clinical implications, and its dynamics during weight-loss are sparse. We investigated the effect of long-term weight-loss induced intervention diets on dynamics of renal-sinus-fat, an ectopic fat depot, and %renal-parenchymal-fat, lipid accumulation within the renal parenchyma. Methods We randomized 278 participants with abdominal obesity/dyslipidemia to low-fat or Mediterranean/low-carbohydrate diets, with or without exercise. We quantified renal-sinus-fat and %renal-parenchymal-fat by whole body magnetic-resonance-imaging. Results Participants (age = 48 years; 89% men; body-mass-index = 31 kg/m2 ) had 86% retention to the trial after 18 months. Both increased renal-sinus-fat and %renal-parenchymal-fat were directly associated with hypertension, and with higher abdominal deep-subcutaneous-adipose-tissue and visceral-adipose-tissue (p of trend < 0.05 for all) after adjustment for body weight. Higher renal-sinus-fat was associated with lower estimated-glomerular-filtration-rate and with higher microalbuminuria and %HbA1C beyond body weight. After 18 months of intervention, overall renal-sinus-fat (−9%; p < 0.05 vs. baseline) but not %renal-parenchymal-fat (−1.7%; p = 0.13 vs. baseline) significantly decreased, and similarly across the intervention groups. Renal-sinus-fat and %renal-parenchymal-fat changes were correlated with weight-loss per-se (p < 0.05). In a model adjusted for age, sex, and visceral-adipose-tissue changes, 18 months reduction in renal-sinus-fat associated with decreased pancreatic, hepatic and cardiac fats (p < 0.05 for all) and with decreased cholesterol/high-density lipoprotein-cholesterol (HDL-c) (β = 0.13; p = 0.05), triglycerides/HDL-c (β = 0.13; p = 0.05), insulin (β = 0.12; p = 0.05) and gamma glutamyl transpeptidase (β = 0.24; p = 0.001), but not with improved renal function parameters or blood pressure. Decreased intake of sodium was associated with a reduction in %renal-parenchymal-fat, after adjustment for 18 months weight-loss (β = 0.15; p = 0.026) and hypertension (β = 0.14; p = 0.04). Conclusions Renal-sinus-fat and renal-parenchymal-fat are fairly related to weight-loss. Decreased renal-sinus-fat is associated with improved hepatic parameters, independent of changes in weight or hepatic fat, rather than with improved renal function or blood pressure parameters. ClinicalTrials.govIdentifier NCT01530724.