Details

Autor(en) / Beteiligte

• Heydarirad, Ghazaleh
• Rezaeizadeh, Hossein
• Choopani, Rasool
• Mosavat, Seyed Hamdollah
• Ameri, Ahmad

Titel

Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia： a randomized, open-label, active-controlled trial

Ist Teil von

• Journal of integrative medicine, 2017-05, Vol.15 (3), p.201-208

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• BACKGROUND： Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers （HNC）. However, conventional medicine lacks an effective treatment for radiation-induced xerostomia. OBJECTIVE： Synthesizing the traditional use ofAIcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life （QOL） of HNC patients with radiation-induced xerostomia. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This study is a randomized, double-arm, open-label active-controlled clinical trial. We evaluated the effect ofA. digitata and M. sy/vestris on QOL of HNC patients with radiation-induced xerostomia compared with Hypozalix （artificial saliva）. Patients were enrolled from the Imam Hossein Hospital＇s oncology clinic in Shahid Beheshti University of Medica Sciences. Tehran, Iran. MAIN OUTCOME MEASURES： Primary outcome measures in this trial were changes in patients＇ QOL assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Head and Neck Module （EORTC QLQ-H＆N 35）. RESULTS： Between-group analysis showed that the intervention group patients obtained significantly lower （better） total EORTC QLQ-H＆N 35 scores as compared to the control group at the end of the intervention period （P = 0.007）. Mean scores of dry mouth of EORTC QLQ-H＆N 35 was also significantly lower （better） in the intervention group as compared to the control group （P = 0.017）.