Details

Autor(en) / Beteiligte

• Dias, Ingrid B. F.
• Panazzolo, Diogo G.
• Marques, Marcela F.
• Paredes, Bruno D.
• Souza, Maria G. C.
• Manhanini, Diogo P.
• Morandi, Verônica
• Farinatti, Paulo T. V.
• Bouskela, Eliete
• Kraemer-Aguiar, Luiz G.

Titel

Relationships between emerging cardiovascular risk factors, z-BMI, waist circumference and body adiposity index (BAI) on adolescents

Ist Teil von

• Clinical endocrinology (Oxford), 2013-11, Vol.79 (5), p.667-674

Ort / Verlag

Oxford: Blackwell Publishing Ltd

Erscheinungsjahr

2013

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Objective The body adiposity index (BAI) has been recently proposed as an alternative index to body mass index (BMI) and waist circumference (WC) to evaluate adiposity in adults, with special focus on its ability to discriminate gender specificities on adiposity. Endothelial dysfunction, circulating endothelial cells (CECs), endothelin‐1 and adipocytokines are all related to atherosclerosis and nowadays considered as markers of emerging cardiovascular (CV) risk. This study aimed to determine in normal weight and obese adolescents which measures of body composition (BAI and z‐BMI) or distribution (WC) correlate better with emerging CV risk markers. Patients Forty adolescents were selected according to BMI: normal weight (n = 20; 7 girls/13 boys, 14·7 ± 1·4 years, 53·4 ± 6·0 kg, z‐BMI 0·6 ± 0·1) and obese ones (n = 20; 13 girls/7 boys, 14·1± 1·0 years, 86·7 ± 11·5 kg, z‐BMI 2·7 ± 0·4). Measurements Body fat and fat mass were measured by dual‐energy X‐ray absorptiometry (DXA). Non‐nutritive skin microvascular reactivity was evaluated by laser Doppler flowmetry with iontophoretic release of vasoactive drugs. Activated CECs were assessed by flow cytometric analysis. Results In adolescents, the measurement of % fat by DXA showed high correlation with BAI (ρ = 0·75, P < 0·0001), z‐BMI (r = 0·84, P < 0·0001) and WC (r = 0·83, P < 0·0001). Endothelin‐1 and activated CECs did not correlate with any anthropometric measures while adipocytokines expressed variable associations among them. Endothelium‐dependent vasodilation showed higher correlation with BAI (r = −0·51, P < 0·0001) compared to z‐BMI (r = −0·40, P < 0·001) or WC (r = −0·45, P < 0·001), specially on females. Conclusions BAI was associated with emerging CV risk markers in adolescents but further research is needed to evaluate its potential in clinical and epidemiological sets.