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Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults
Cancer research (Chicago, Ill.), 2016-10, Vol.76 (20), p.6076-6083
Campbell, Peter T
Newton, Christina C
Freedman, Neal D
Koshiol, Jill
Alavanja, Michael C
Beane Freeman, Laura E
Buring, Julie E
Chan, Andrew T
Chong, Dawn Q
Datta, Mridul
Gaudet, Mia M
Gaziano, J Michael
Giovannucci, Edward L
Graubard, Barry I
Hollenbeck, Albert R
King, Lindsey
Lee, I-Min
Linet, Martha S
Palmer, Julie R
Petrick, Jessica L
Poynter, Jenny N
Purdue, Mark P
Robien, Kim
Rosenberg, Lynn
Sahasrabuddhe, Vikrant V
Schairer, Catherine
Sesso, Howard D
Sigurdson, Alice J
Stevens, Victoria L
Wactawski-Wende, Jean
Zeleniuch-Jacquotte, Anne
Renehan, Andrew G
McGlynn, Katherine A
2016
Details
Autor(en) / Beteiligte
Campbell, Peter T
Newton, Christina C
Freedman, Neal D
Koshiol, Jill
Alavanja, Michael C
Beane Freeman, Laura E
Buring, Julie E
Chan, Andrew T
Chong, Dawn Q
Datta, Mridul
Gaudet, Mia M
Gaziano, J Michael
Giovannucci, Edward L
Graubard, Barry I
Hollenbeck, Albert R
King, Lindsey
Lee, I-Min
Linet, Martha S
Palmer, Julie R
Petrick, Jessica L
Poynter, Jenny N
Purdue, Mark P
Robien, Kim
Rosenberg, Lynn
Sahasrabuddhe, Vikrant V
Schairer, Catherine
Sesso, Howard D
Sigurdson, Alice J
Stevens, Victoria L
Wactawski-Wende, Jean
Zeleniuch-Jacquotte, Anne
Renehan, Andrew G
McGlynn, Katherine A
Titel
Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults
Ist Teil von
Cancer research (Chicago, Ill.), 2016-10, Vol.76 (20), p.6076-6083
Ort / Verlag
United States
Erscheinungsjahr
2016
Link zum Volltext
Quelle
Electronic Journals Library
Beschreibungen/Notizen
Incidence rates for liver cancer have increased 3-fold since the mid-1970s in the United States in parallel with increasing trends for obesity and type II diabetes mellitus. We conducted an analysis of baseline body mass index (BMI), waist circumference (WC), and type II diabetes mellitus with risk of liver cancer. The Liver Cancer Pooling Project maintains harmonized data from 1.57 million adults enrolled in 14 U.S.-based prospective studies. Cox regression estimated HRs and 95% confidence intervals (CI) adjusted for age, sex, study center, alcohol, smoking, race, and BMI (for WC and type II diabetes mellitus). Stratified analyses assessed whether the BMI-liver cancer associations differed by hepatitis sera-positivity in nested analyses for a subset of cases (n = 220) and controls (n = 547). After enrollment, 2,162 incident liver cancer diagnoses were identified. BMI, per 5 kg/m , was associated with higher risks of liver cancer, more so for men (HR = 1.38; 95% CI, 1.30-1.46) than women (HR = 1.25; 95% CI, 1.17-1.35; P = 0.02). WC, per 5 cm, was associated with higher risks of liver cancer, approximately equally by sex (overall, HR = 1.08; 95% CI, 1.04-1.13). Type II diabetes mellitus was associated with higher risk of liver cancer (HR = 2.61; 95% CI, 2.34-2.91). In stratified analyses, there was a null association between BMI and liver cancer risk for participants who were sera-positive for hepatitis. This study suggests that high BMI, high WC, and type II diabetes mellitus are associated with higher risks of liver cancer and that the association may differ by status of viral hepatitis infection. Cancer Res; 76(20); 6076-83. ©2016 AACR.
Sprache
Englisch
Identifikatoren
ISSN: 0008-5472
eISSN: 1538-7445
DOI: 10.1158/0008-5472.can-16-0787
Titel-ID: cdi_proquest_miscellaneous_1897383805
Format
–
Schlagworte
Adult
,
Aged
,
Body Mass Index
,
Diabetes Mellitus, Type 2 - complications
,
Female
,
Humans
,
Liver Neoplasms - etiology
,
Male
,
Middle Aged
,
Proportional Hazards Models
,
Prospective Studies
,
Risk Factors
,
Waist Circumference
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