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The Effect of Pulmonary Hypertension on Aerobic Exercise Capacity in Lung Transplant Candidates with Advanced Emphysema
Ist Teil von
Lung, 2015-04, Vol.193 (2), p.223-229
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2015
Quelle
SpringerLink
Beschreibungen/Notizen
Purpose
Mild pulmonary hypertension (PH) in patients with advanced COPD is common, but its effects on exercise capacity are controversial. The objective of our study was to investigate the effects of mild PH (35 > mPAP ≥ 25 mmHg) on exercise capacity in patients with advanced emphysema, candidates for lung transplantation.
Methods
We retrospectively reviewed and compare the data from right heart catheterization and cardiopulmonary exercise test, performed in patients with advanced emphysema, candidate for lung transplantation.
Results
Twenty patients with emphysema and no PH and 24 patients with emphysema associated with mild PH included in the study. Both patient groups had severe airways obstruction with markedly reduced FEV1 (24.9 %
P
± 8.9 and 25.9 %
P
± 11.7, respectively), and severely reduced DLCO (35.2 %
P
± 17.3 and 39.2 %
P
± 15.9). Both patients group demonstrated mark reduction in maximum workload and peak VO
2
together with increased ventilatory equivalent for CO
2
and extremely low breathing reserve. There was no correlation between mPAP and any of the exercise measurement.
Conclusions
Our study suggests that exercise capacity in patients with advanced emphysema is limited by the ventilatory impairment and the presence of mild PH has no farther impact on exercise capability.