Details

Autor(en) / Beteiligte

• Gauthier, J
• Castagna, L
• Garnier, F
• Guillaume, T
• Socié, G
• Maury, S
• Maillard, N
• Tabrizi, R
• Marchand, T
• Malfuson, J
• Gac, A
• Gyan, E
• Mercier, M
• Béguin, Y
• Delage, J
• Turlure, P
• Marçais, A
• Nguyen, S
• Dulery, R
• Bay, J
• Huynh, A
• Daguindau, E
• Cornillon, J
• Régny, C
• Michallet, M
• Peffault de Latour, R
• Yakoub-Agha, I
• Blaise, D

Titel

Reduced-intensity and non-myeloablative allogeneic stem cell transplantation from alternative HLA-mismatched donors for Hodgkin lymphoma: a study by the French Society of Bone Marrow Transplantation and Cellular Therapy

Ist Teil von

• Bone marrow transplantation (Basingstoke), 2017-05, Vol.52 (5), p.689-696

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Nexis

Beschreibungen/Notizen

• Allogeneic stem cell transplantation (allo-SCT) following a non-myeloablative (NMA) or reduced-intensity conditioning (RIC) is considered a valid approach to treat patients with refractory/relapsed Hodgkin lymphoma (HL). When an HLA-matched donor is lacking a graft from a familial haploidentical (HAPLO) donor, a mismatched unrelated donor (MMUD) or cord blood (CB) might be considered. In this retrospective study, we compared the outcome of patients with HL undergoing a RIC or NMA allo-SCT from HAPLO, MMUD or CB. Ninety-eight patients were included. Median follow-up was 31 months for the whole cohort. All patients in the HAPLO group (N=34) received a T-cell replete allo-SCT after a NMA (FLU-CY-TBI, N=31, 91%) or a RIC (N=3, 9%) followed by post-transplant cyclophosphamide. After adjustment for significant covariates, MMUD and CB were associated with significantly lower GvHD-free relapse-free survival (GRFS; hazard ratio (HR)=2.02, P=0.03 and HR=2.43, P=0.009, respectively) compared with HAPLO donors. In conclusion, higher GRFS was observed in Hodgkin lymphoma patients receiving a RIC or NMA allo-SCT with post-transplant cyclophosphamide from HAPLO donors. Our findings suggest they should be favoured over MMUD and CB in this setting.