Details

Autor(en) / Beteiligte

• Davoudi, Samaneh
• Ebrahimiadib, Nazanin
• Yasa, Cagla
• Sevgi, Damla D.
• Roohipoor, Ramak
• Papavasilieou, Evangelia
• Comander, Jason
• Sobrin, Lucia

Titel

Outcomes in Autoimmune Retinopathy Patients Treated With Rituximab

Ist Teil von

• American journal of ophthalmology, 2017-08, Vol.180, p.124-132

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• To evaluate clinical and ancillary testing, including adaptive optics, outcomes in autoimmune retinopathy (AIR) patients treated with rituximab. Retrospective, interventional case series. patients: Sixteen AIR patients treated with rituximab. observation procedures: All patients were treated with a loading and maintenance dose schedule of intravenous rituximab. Visual acuity (VA), electroretinography (ERG), and spectral-domain optical coherence tomography (SDOCT) and visual field (VF) results were recorded. A subset of patients was also imaged using adaptive optics scanning laser ophthalmoscopy (AO-SLO). main outcome measures: Rates of VA change before vs after rituximab initiation were compared with mixed-model linear regression. The rate of visual decline was significantly less after rituximab initiation compared with the rate of visual decline prior to rituximab initiation (P = .005). Seventy-seven percent of eyes had stable or improved VA 6 months after rituximab initiation. Amplitudes and implicit times on ERG, mean deviation on VF, central subfield mean thickness, and total macular volume did not decrease to a significant degree over the rituximab treatment period. Six eyes had serial AO-SLO imaging. Cone densities did not change significantly over the treatment period. VA was stable or improved in a majority of AIR patients while they were being treated with rituximab. OCT and ERG parameters, as well as AO-SLO cone densities, were stable during treatment. Studies with additional patients and longer follow-up periods are needed to further explore the utility of rituximab in the management of AIR.