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Development of a novel alginate‐polyvinyl alcohol‐hydroxyapatite hydrogel for 3D bioprinting bone tissue engineered scaffolds
Journal of biomedical materials research. Part A, 2017-05, Vol.105 (5), p.1457-1468
Bendtsen, Stephanie T.
Quinnell, Sean P.
Wei, Mei
2017
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Bendtsen, Stephanie T.
Quinnell, Sean P.
Wei, Mei
Titel
Development of a novel alginate‐polyvinyl alcohol‐hydroxyapatite hydrogel for 3D bioprinting bone tissue engineered scaffolds
Ist Teil von
Journal of biomedical materials research. Part A, 2017-05, Vol.105 (5), p.1457-1468
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Three‐dimensional printed biomaterials used as personalized tissue substitutes have the ability to promote and enhance regeneration in areas of defected tissue. The challenge with 3D printing for bone tissue engineering remains the selection of a material with optimal rheological properties for printing in addition to biocompatibility and capacity for uniform cell incorporation. Hydrogel biomaterials may provide sufficient printability to allow cell encapsulation and bioprinting of scaffolds with uniform cell distribution. In this study, a novel alginate‐polyvinyl alcohol (PVA)‐hydroxyapatite (HA) hydrogel formulation with optimal rheological properties for 3D bioprinting of mouse calvaria 3T3‐E1 (MC3T3) cells into scaffolds of high shape fidelity has been developed. A systematic investigation was conducted to determine the effect of varying concentrations of alginate, phosphate, calcium, and the PVA‐HA suspension in the formulation on the resulting viscosity and thus printability of the hydrogel. HA, the main mineral component in natural bone, was incorporated into the hydrogel formulation to create a favorable bone‐forming environment due to its excellent osteoconductivity. Degradation studies in α‐MEM cell culture media showed that the 3D printed alginate‐PVA‐HA scaffolds remained in‐tact for 14 days. MC3T3 cells were well distributed and encapsulated throughout the optimal hydrogel formulation and expressed high viability through the completion of the 3D printing process. Thus, the development of this novel, osteoconductive, biodegradable, alginate‐PVA‐HA formulation and its ability to 3D bioprint tissue engineered scaffolds make it a promising candidate for treating personalized bone defects. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1457–1468, 2017.
Sprache
Englisch
Identifikatoren
ISSN: 1549-3296
eISSN: 1552-4965
DOI: 10.1002/jbm.a.36036
Titel-ID: cdi_proquest_miscellaneous_1893917391
Format
–
Schlagworte
3-D printers
,
3D printing
,
Alcohols
,
alginate
,
Alginates
,
Alginates - chemistry
,
Alginic acid
,
Animals
,
Biocompatibility
,
Biodegradability
,
Biodegradation
,
Biomaterials
,
Biomedical materials
,
bioprinting
,
Bone and Bones - chemistry
,
Bone biomaterials
,
bone tissue engineering
,
Bones
,
Calcium
,
Calcium alginate
,
Calcium phosphates
,
Calvaria
,
Cell culture
,
Cell Line
,
Culture media
,
Durapatite - chemistry
,
Encapsulation
,
Environmental degradation
,
Formulations
,
Glucuronic Acid - chemistry
,
Hexuronic Acids - chemistry
,
hydrogel
,
Hydrogels
,
Hydrogels - chemistry
,
Hydroxyapatite
,
Materials Testing
,
Mice
,
Osteoconduction
,
Polyvinyl alcohol
,
Polyvinyl Alcohol - chemistry
,
Printing
,
Printing, Three-Dimensional
,
Regeneration
,
Rheological properties
,
Rheology
,
Scaffolds
,
Surgical implants
,
Three dimensional printing
,
Tissue Engineering
,
Tissue Scaffolds - chemistry
,
Viability
,
Viscosity
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