Details

Autor(en) / Beteiligte

• Pettinari, Riccardo
• Petrini, Agnese
• Marchetti, Fabio
• Pettinari, Claudio
• Riedel, Tina
• Therrien, Bruno
• Dyson, Paul J.

Titel

Arene–Ruthenium(II) Complexes with Bioactive ortho‐Hydroxydibenzoylmethane Ligands: Synthesis, Structure, and Cytotoxicity

Ist Teil von

• European journal of inorganic chemistry, 2017-03, Vol.2017 (12), p.1800-1806

Ort / Verlag

Weinheim: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Wiley Online Library

Beschreibungen/Notizen

• The synthesis of a series of neutral arene–ruthenium(II) complexes (arene = p‐cymene, hexamethylbenzene, and benzene) [(arene)Ru(HDB)Cl] derived from the reaction of the appropriate arene–ruthenium(II) dimers and ortho‐hydroxydibenzoylmethane (HDBH), a potent inhibitor of cell proliferation, is described. In addition, related ionic complexes [(arene)Ru(HDB)(PTA)](SO3CF3) (PTA = 1,3,5‐triaza‐7‐phosphaadamantane) have been prepared. The structure of three complexes has been confirmed by X‐ray crystallography. The cytotoxicity of the complexes has been evaluated against human ovarian carcinoma cells (A2780 and A2780cisR), as well as against nontumorigenic human embryonic kidney (HEK293) cells, and compared to the free ligand and cisplatin. Two of the complexes, that is from the first series with p‐cymene and hexamethylbenzene, display relevant activities against the cisplatin‐resistant A2780cisR cancer cell line. Arene–RuII complexes of ortho‐hydroxydibenzoylmethane show an intramolecular H bond in both the solid state and solution. They display good cytotoxicity in vitro against human ovarian carcinoma A2780 and even superior activity against A2780cisR cells.