Brain research, 2003-08, Vol.980 (1), p.117-120
2003
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Details
- Autor(en) / Beteiligte
- Titel
- Evidence for an antihyperalgesic effect of venlafaxine in vincristine-induced neuropathy in rat
- Ist Teil von
- Brain research, 2003-08, Vol.980 (1), p.117-120
- Ort / Verlag
- London: Elsevier B.V
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Venlafaxine, a new antidepressant with fewer side effects, could be of interest to reduce neuropathic pain following antineoplasic drug treatment. In the present study, we demonstrated that venlafaxine inhibits hyperalgesia in a new rat model of neuropathy induced by the antineoplasic drug vincristine, and exerts its effect preferentially via supraspinal and spinal mechanisms.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-8993eISSN: 1872-6240DOI: 10.1016/S0006-8993(03)02946-9Titel-ID: cdi_proquest_miscellaneous_18939069
- Format
- –
- Schlagworte
- Analgesics - pharmacology, Animals, Antidepressants, Antidepressive Agents, Second-Generation - pharmacology, Antineoplasic drug, Antineoplastic Agents, Phytogenic - adverse effects, Biological and medical sciences, C reflex, Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction, Cyclohexanols - pharmacology, Disease Models, Animal, Hyperalgesia - chemically induced, Hyperalgesia - drug therapy, Male, Medical sciences, Nervous system (semeiology, syndromes), Neuralgia - chemically induced, Neuralgia - drug therapy, Neurology, Neuropathic pain, Paw pressure, Rat, Rats, Rats, Sprague-Dawley, Serotonin Uptake Inhibitors - pharmacology, Venlafaxine, Venlafaxine Hydrochloride, Vincristine - adverse effects