Details
- Autor(en) / Beteiligte
- Titel
- Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity
- Ist Teil von
- Chemical communications (Cambridge, England), 2014-12, Vol.50 (98), p.15565-15568
- Ort / Verlag
- England
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1359-7345eISSN: 1364-548XDOI: 10.1039/c4cc06728bTitel-ID: cdi_proquest_miscellaneous_1893902108
- Format
- –
- Schlagworte
- Acetal copolymers, Acetals - chemical synthesis, Acetals - chemistry, Adipose Tissue - cytology, Animals, Cell Line, Copolymers, Degradation, DNA - administration & dosage, DNA - genetics, Efficiency, Genes, Hydrolysis, Luciferases - genetics, Methacrylates - chemical synthesis, Methacrylates - chemistry, Nucleic acids, Nylons - chemical synthesis, Nylons - chemistry, Plasmids - administration & dosage, Plasmids - genetics, Rabbits, Stem Cells - metabolism, Synthesis (chemistry), Toxicity, Transfection