Chemical communications (Cambridge, England), 2014-01, Vol.50 (57), p.7632-7635
2014
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- Autor(en) / Beteiligte
- Titel
- A hyaluronic acid-methotrexate conjugate for targeted therapy of rheumatoid arthritis
- Ist Teil von
- Chemical communications (Cambridge, England), 2014-01, Vol.50 (57), p.7632-7635
- Ort / Verlag
- England
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In an effort to improve the therapeutic efficacy of methotrexate (MTX), we prepared the hyaluronic acid-MTX conjugate for targeted therapy of rheumatoid arthritis (RA). Owing to the pH-sensitive nature of the conjugate, MTX was rapidly released under the mildly acidic conditions, similar to the environment of inflamed synovial tissue in RA.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1359-7345eISSN: 1364-548XDOI: 10.1039/c4cc02595dTitel-ID: cdi_proquest_miscellaneous_1893883382
- Format
- –
- Schlagworte
- Adjuvants, Immunologic - administration & dosage, Adjuvants, Immunologic - metabolism, Animals, Antirheumatic Agents - administration & dosage, Antirheumatic Agents - metabolism, Arthritis, Arthritis, Rheumatoid - drug therapy, Arthritis, Rheumatoid - metabolism, Arthritis, Rheumatoid - pathology, Cell Line, Conjugates, Drug Combinations, Drug Delivery Systems - methods, Effectiveness, Hyaluronic Acid - administration & dosage, Hyaluronic Acid - metabolism, Methotrexate, Methotrexate - administration & dosage, Methotrexate - metabolism, Mice, Therapy