Details

Autor(en) / Beteiligte

• Sorigue, Marc
• Juncà, Jordi
• Orna, Elisa
• Romanic, Nevena
• Sarrate, Edurne
• Castellvi, Jordi
• Soler, Montse
• Rodríguez-Hernandez, Ines
• Feliu, Evarist
• Ruiz, Susana

Titel

Retinal vein occlusion and paroxysmal nocturnal hemoglobinuria

Ist Teil von

• Journal of thrombosis and thrombolysis, 2017-07, Vol.44 (1), p.63-66

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disorder associated with increased risk for thrombosis and reduced life expectancy. Retinal vein occlusion (RVO) is a frequent cause of vision loss but its relationship with PNH has not been studied systematically. Patients followed up for RVO in our ophthalmology department were screened for the presence of a PNH clone in peripheral blood by means of flow cytometry. The presence of other well-documented risk factors for RVO was also analyzed. In a series of 110 patients (54 males, median age of 67) we found no evidence of PNH. Most patients (97/110) had cardiovascular risk factors and/or hyperhomocysteinemia (67/110). Inherited thrombophilias were rare (three confirmed cases). Therefore, PNH does not appear to play a role in the development of RVO. However, this finding does not necessarily apply to young patients and/or those with no conventional risk factors for RVO, due to the low number of patients in these subgroups in our population.