Details

Autor(en) / Beteiligte

• Lee, Youn Joo
• Kim, Sung Hun
• Kang, Bong Joo
• Kang, Young Jee
• Yoo, Heesoo
• Yoo, Jaewan
• Lee, Jaeun
• Son, Yo Han
• Grimm, Robert

Titel

Intravoxel incoherent motion (IVIM)‐derived parameters in diffusion‐weighted MRI: Associations with prognostic factors in invasive ductal carcinoma

Ist Teil von

• Journal of magnetic resonance imaging, 2017-05, Vol.45 (5), p.1394-1406

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose To investigate relationships between intravoxel incoherent motion (IVIM) metrics of invasive ductal carcinoma of the breast and prognostic factors. Materials and Methods This retrospective study included a total of 82 masses from 72 patients who underwent 3T breast magnetic resonance imaging (MRI) and diffusion‐weighted imaging. IVIM metrics of tissue diffusivity (Dslow), pseudodiffusivity (Dfast), and perfusion fraction (Dpf) were measured using histogram analysis for whole lesion volumes. We evaluated relationships between IVIM metrics and prognostic factors or subtypes of invasive ductal carcinoma. Results The Dslow 50th, 75th, and 90th percentile metrics were reduced in the estrogen receptor (ER)‐positive group compared with the ER‐negative group (individually, P = 0.044, 0.024, 0.045). Additionally, the Dslow 75th percentile value was a significant differentiator of histologic grade, tumor subtype, and Ki‐67 grouping (individually, P = 0.024, 0.049, 0.016). The Dpf mean, 75th, 90th percentile, skewness, and kurtosis metrics were correlated with the size of ductal carcinoma in situ (DCIS) component (individually, P = 0.034, 0.032, 0.027, 0.013, 0.013). Conclusion The Dslow metrics differentiated between ER‐positive and ‐negative groups, and the Dpf metrics were associated with the size of the DCIS component. Level of Evidence: 4 J. MAGN. RESON. IMAGING 2017;45:1394–1406