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Sustained‐release of naproxen sodium from electrospun‐aligned PLLA–PCL scaffolds
Journal of tissue engineering and regenerative medicine, 2017-04, Vol.11 (4), p.1011-1021
Lui, Yuan Siang
Lewis, Mark P.
Loo, Say Chye Joachim
2017
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Lui, Yuan Siang
Lewis, Mark P.
Loo, Say Chye Joachim
Titel
Sustained‐release of naproxen sodium from electrospun‐aligned PLLA–PCL scaffolds
Ist Teil von
Journal of tissue engineering and regenerative medicine, 2017-04, Vol.11 (4), p.1011-1021
Ort / Verlag
England: Hindawi Limited
Erscheinungsjahr
2017
Quelle
MEDLINE
Beschreibungen/Notizen
Spontaneous tendon healing may result in reduced tissue functionality. In view of this, tissue engineering (TE) emerges as a promising approach in promoting proper tendon regeneration. However, unfavourable post‐surgical adhesion formations restrict adequate tendon healing through the TE approach. Naproxen sodium (NPS), a non‐steroidal anti‐inflammatory drug (NSAID), has been demonstrated to prevent adhesions by inhibiting the inflammatory response. Therefore, in this study, various factors, such as polymer composition, i.e. different poly‐l‐lactic acid (PLLA):polycaprolactone (PCL) ratios, and percentage of water:hexafluoroisopropanol (HFIP; as co‐solvent) ratios, were investigated to understand how these can influence the release of NPS from electrospun scaffolds. By adjusting the amount of water as the co‐solvent, NPS could be released sustainably for as long as 2 weeks. Scaffold breaking strength was also enhanced with the addition of water as the co‐solvent. This NPS‐loaded scaffold showed no significant cytotoxicity, and L929 murine fibroblasts cultured on the scaffolds were able to proliferate and align along the fibre orientation. These scaffolds with desirable tendon TE characteristics would be promising candidates in achieving better tendon regeneration in vivo. Copyright © 2015 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 1932-6254
eISSN: 1932-7005
DOI: 10.1002/term.2000
Titel-ID: cdi_proquest_miscellaneous_1891876456
Format
–
Schlagworte
adhesion formation
,
Animals
,
Cell Survival - drug effects
,
Cells, Cultured
,
Delayed-Action Preparations - pharmacology
,
Drug Liberation
,
electrospinning
,
Mice
,
Naproxen - pharmacology
,
naproxen sodium
,
PCL
,
Photoelectron Spectroscopy
,
PLLA
,
Polyesters - chemistry
,
Regenerative medicine
,
tendon regeneration
,
Tissue engineering
,
Tissue Engineering - methods
,
Tissue Scaffolds - chemistry
,
Water - chemistry
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