Brain, behavior, and immunity, 2017-08, Vol.64, p.220-231
2017
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes
- Ist Teil von
- Brain, behavior, and immunity, 2017-08, Vol.64, p.220-231
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Brain pericytes express NOD-like and Toll-like pattern recognition receptors. • Expression of NLRs and TLRs is regulated by inflammatory mediators. • No canonical inflammasome activation could be detected in human cerebral pericytes. • Pericytes secrete active IL-1β in response to non-canonical inflammasome activation. • Pericytes might have an important regulatory role in neuroinflammation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591eISSN: 1090-2139DOI: 10.1016/j.bbi.2017.04.010Titel-ID: cdi_proquest_miscellaneous_1891145415
- Format
- –
- Schlagworte
- Allergy and Immunology, Blood–brain barrier (BBB), Brain - metabolism, Cells, Cultured, Cerebral pericyte, Gene Expression Regulation, Humans, IL-1β, Inflammasome, Inflammasomes - metabolism, Interleukin-1beta - metabolism, NOD-like receptor (NLR), Non-canonical, pattern recognition receptor (PRR), Pericytes - metabolism, Psychiatry, Receptors, Pattern Recognition - metabolism, Signal Transduction, Toll-like receptor (TLR)