Bulletin of experimental biology and medicine, 2017-04, Vol.162 (6), p.746-749
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Experimental Study of a Radiopharmaceutical Agent Based on Modified Fatty Acid Labeled with Technetium-99m
- Ist Teil von
- Bulletin of experimental biology and medicine, 2017-04, Vol.162 (6), p.746-749
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Using rat model of coronary occlusion, we studied pharmacokinetics and the efficiency of a new radiopharmaceutical agent 99m Tc-PDA-DTPA intended for diagnostics of changes in myocardial metabolism and its analogue 123 I-PMPDA. 99m Tc-PDA-DTPA was eliminated mostly by the kidneys and maximal concentration in the heart was attained within 60 min after intravenous injection; no accumulation in the area of myocardial infarction was observed. The studied substance was inferior to its analogue 123I-PMPDA by the quality of scintigraphic visualization of the heart.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-017-3703-4Titel-ID: cdi_proquest_miscellaneous_1891132730
- Format
- –
- Schlagworte
- Animals, Biomedical and Life Sciences, Biomedicine, Cardiology, Cell Biology, Coronary Occlusion - surgery, Fatty acids, Fatty Acids - chemistry, Fatty Acids - pharmacokinetics, Heart - diagnostic imaging, Internal Medicine, Intravenous administration, Iodine Radioisotopes, Iodobenzenes - chemistry, Iodobenzenes - pharmacokinetics, Kidney - diagnostic imaging, Kidney - metabolism, Laboratory Medicine, Liver - diagnostic imaging, Liver - metabolism, Male, Myocardial infarction, Myocardial Infarction - diagnostic imaging, Myocardial Infarction - metabolism, Myocardial Perfusion Imaging - methods, Occlusion, Pathology, Pharmaceuticals, Pharmacokinetics, Radiation measurement, Radioisotopes, Radionuclide Imaging - methods, Radiopharmaceuticals - chemistry, Radiopharmaceuticals - pharmacokinetics, Rats, Rats, Wistar, Rodents, Staining and Labeling - methods, Technetium, Technetium - chemistry, Technetium - pharmacokinetics, Tissue Distribution